This volume of Nutrients includes twelve independent contributions that focus on – Recent advances in Omega-3: health benefits, sources, products and bioavailability. As a group of molecules, the omega-3 long-chain (≥C20) polyunsaturated fatty acids (LC-PUFA, also termed LC omega-3), are required for or essential for optimal human and animal health, yet modern western and other diets are often lacking in these key ingredients.