The aim of this book is to demonstrate the necessity of the multidisciplinary approaches with minimally invasive treatment procedures and the clinical protocol for the esthetic treatment of diastema with an integrated orthodontic, periodontal, and restorative approach. In addition, it provides a comprehensive treatment planning by the analysis of the study models, photographs, occlusion, and soft and hard tissue as well as facial analysis which should also be evaluated for a satisfactory treatment outcome. Each chapter addresses various aspects of diastema starting from its etiology toward clinical considerations, esthetic evaluations, occlusion, and periodontal considerations with interdisciplinary treatment procedures and treatment options. Specific tips in the relevant chapters were also highlighted in the text for the clinicians regarding the application procedures.